Significance of p53 and C-erbB-2 expression in endemic and AIDS-related Kaposi’s sarcoma in Africa
- VernacularTitle:p53和C-erbB-2在非洲地方性和AIDS相关Kaposi肉瘤中表达的意义
- Author:
Shuhua ZHANG
;
Youbin RUAN
;
Kitinya JN
;
Yu MA
;
Yuhong ZHU
;
Jinxiu LI
- Publication Type:Journal Article
- Keywords:
Kaposi's sarcoma;
AIDS;
hybridization in situ;
immunohistochemistry;
Africa
- From:China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the significance of p53 protein, p53mRNA, and C erbB 2 protein expressions in Africa endemic and AIDS related Kaposi's sarcoma (KS).Methods:Immunohistochemistry and hybridization in situ were performed with p53 and C erbB 2 in 30 cases with endemic and AIDS related KS.The degree of pasitivity of p53 and C erbB 2 in KS tissues were measured with image analysis system. KS was classified into three types, i.e., angiomatous type, spindle cell type, and mixed type according to the proportion of blood vessel components and spindle cells in the lesions.Results:The degree of positivity of p53 protein was stronger in spindle cell type than that in angiomatous type ( P
