The prognostic factors of non-Hodgkin's lymphoma in nasal cavity
- VernacularTitle:鼻腔非霍奇金淋巴瘤的预后及影响因素
- Author:
Yuanquan LU
;
- Publication Type:Journal Article
- Keywords:
nasal neoplaslm;
non- Hodgkin's lymphoma;
prognosis
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To analyze the prognostic factors of non-Hodgkin's lymphoma in nasal cavity.Methods:From Feb. 1985 to Jul. 1996, 143 patientsof non- Hodgkin's lymphoma in nasal cavity have been treated in our hospital by radiotherapy alone, chemotherapy alone and radiotherapy with chemotherapy.Results:The complete response rate of all 143 patients was 53.1%(70/143). The main failure site is distant extranodal infiltration especially the invasion of skin. Failure at primary site and lymph node is not common. The main factor influencing local and distant failure is the stage of disease.The failure rate of stage Ⅰ, stageⅡ and stageⅢ-Ⅳ is 29.7%(30/101),87.5%(28/32) and 90.0%(9/10), respectively . The distant extranode invasion rate is 54.2%(45/83) and 35.9%(14/39) in T cell and B cell type disease respectively. In those stage Ⅰ patients with lesions beyond nasal cavity , the distant failure rate have not shown any difference between groups of radiotherapy alone and radiotherapy with chemotherapy. In contrast, in patients of stageⅡ～Ⅳ disease, the distant failure rate is less in patients received radiotherapy with chemotherapy than in patients received radiotherapy alone. Conclusions:Chemotherapy could improve the survival rate and decrease the distant failures for the patients of advanced non- Hodgkin's lymphoma in nasal cavity. The failures always occur in 2 weeks after initial treatment and the prognosis of the failure patients is very poor.
