Progress in the research of tumor lymphangiogenesis
- VernacularTitle:肿瘤淋巴管生成的研究进展
- Author:
Chao YAN
;
Zhenggang ZHU
;
- Publication Type:Journal Article
- Keywords:
tumor;
lymphangiogenesis;
vascular endothelial growth factor;
lymph node metastasis
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Lymphatic vessels are important for the spread of solid tumors, and recent researches indicated that lymphangiogenic factors(VEGF C and VEGF D)could stimulate lymphangiogenesis in tumors by activating their receptors on the lymphatic endothelial cells, then enhance the incidence of lymph node metastasis. In addition, inhibition of VEGFR 3 signaling could suppress tumor lymphangiogenesis and metastasis to lymph nodes, thus, inhibition of lymphangiogenesis can be expected to be a new method of blocking tumor metastasis.
