Detection of serum chemokines and their receptors on peripheral blood CD3~+T lymphocytes of patients with recurrent genital herpes
- VernacularTitle:复发性生殖器疱疹患者外周血趋化性细胞因子及其受体的研究
- Author:
Mingxia ZHANG
;
Qifeng QIAN
;
- Publication Type:Journal Article
- Keywords:
Recurrent genital herpes;
Chemokines;
Receptors
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the role of serum chemokines and their receptors expression in pathogenesis of recurrent genital herpes(RGH).Methods:Serum levels of interleukin 8(IL 8),interferon ? inducible protein 10 (IP 10),monocyte chemotactic protein1(MCP 1),macrophage inflammatory protein 1?(MIP 1?),regulated upon activation,normal T cell expressed and secreted factor(RANTES) and macrophage derived chemokine(MDC)were determined by enzyme linked immunosorbent assay in 20 patients with RGH and 30 normal controls, meanwhile, a two color immunofluorescent staining of chemokine receptors CCR2,CCR5,CXCR1 and CXCR3 on peripheral blood CD3 +T lymphocytes of patients with RGH were analyzed by flow cytometer.Results:Serum levels of RANTES were lower in patients with RGH than that in controls(P
