Detection of lectin-reactive alpha-fetoprotein and its clinical value
- VernacularTitle:AFP异质体检测及其临床应用价值
- Author:
Zhaoyun LI
;
Xiaoyu WU
;
Weiqiang LAI
;
Al ET
- Publication Type:Journal Article
- Keywords:
Lectin reactive alpha fetoprotein;
Primary hepatocellular carcinoma;
Leng culinaris agglulinin
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical value of lectin reactive alpha fetoprotein(AFP) detection in primary hepatocellular carcinoma (PHC) and benign liver diseases.Methods:According to the different affinity with AFP, AFP L 3 was detected by affinity immunoelectrophoresis blotting method, AFP detected by Chemiluminescent Immunoassay.Results:Taking AFP L 3≥15% as the diagnosis criteria of PHC,the sensitivity was 91.1%,the specificity in differential diagnosis in chronical liver diseases was 95.0%,the levels of AFP L 3 has no correlation to serum AFP levels and the sizes of PHC.Conclusion:It is of great clinical value to detect AFP L 3 and serum AFP levels for PHC in early diagnosis and benign differential diagnosis in liver diseases. [
