Current status of targeting antiapoptotic gene by antisense oligodeoxynucleotides
- VernacularTitle:以凋亡抑制基因为靶点的反义寡核苷酸研究现状
- Author:
Jianhui YANG
;
Jun YAN
;
Guohua LI
;
- Publication Type:Journal Article
- Keywords:
antisense oligodeoxynucleotide;
apoptosis;
malignancy
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Diminished apoptosis,due to overexpression of antiapoptotic proteins, is involved in tumorigenesis and chemoresistance. Antisense oligodeoxynucleotide (ASODN) has been used to inhibit the expression of antiapoptotic proteins(f.g bcl 2, bcl x L , survivin),aimed to induce apoptosis or enhance chemosensitivity.The combination of ASODN with conventional treatment is possibly a reasonable approach in furture cancer therapy. [
