Progress of epidermal growth factor receptor and tyrosine kinase inhibitors in the cancer therapy
- VernacularTitle:表皮生长因子受体与酪氨酸激酶抑制剂在肿瘤防治中的应用进展
- Author:
Min ZHANG
;
Xin ZHANG
;
Chunxue BAI
;
- Publication Type:Journal Article
- Keywords:
epidermal growth factor receptor;
signal transduction system;
non small cell lung cancer;
tyrosine kinase inhibitors
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The signal transduction system induced by epidermal growth factor receptor(EGFR) regulates cell cycle ,modulates cell growth and differentiation and improves damage repair.The overexpression of EGFR in several epithelial tumors including non small cell lung cancer(NSCLC) forecasts low survival rate, poor prognosis and metastasis. Thereby EGFR can be a potential target for gene therapy. Tyrosine kinase inhibitors(TKIs) selectively inhibit tyrosine kinase activity,supress tumor growth ,and increase the sensitivity of radio chemotherapy. [
