Effect of Urinastatin on Microcirculation of Extrapancreatic Organs in Rats with Acute Necrotizing Pancreatitis
- VernacularTitle:急性坏死性胰腺炎胰外器官微循环改变及乌司他丁的影响
- Author:
Jianguo QU
;
Jianxin ZHANG
;
Guozuo CHENG
;
- Publication Type:Journal Article
- Keywords:
Acute necrotizing pancreatitis Microcirculation Urinastatin
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of urinastatin(UTI) on microcirculation of extra pancreatic organs in rats with acute necrotizing pancreatitis(ANP). Methods A total of 48 rats were randomized into control group, ANP group and UTI group. The model of ANP was established by uniform injection of 5% sodium taurocholate solution under pancreatic capsule, only injection of normal saline in control group. Then the rats of UTI group were injected with UTI through the femoral vein, the rats of ANP group and control group were injected with normal saline. The blood flow of lung, kidney and distal small intestine was measured by radioactive biomicrosphere technique at 2 h and 6 h after ANP.Results Compared with the control group, the blood flow of lung, kidney and intestine was decreased significantly in the ANP group at the 2 h and 6 h after ANP ( P
