Clinicopathological Significance of the Integrin ?_5?_1 Expression and Microvessel Density in Gastric Cancer
- VernacularTitle:整合蛋白?_5?_1的表达与胃癌生物学行为及微血管密度的关系
- Author:
Yejiang ZHOU
;
De SHI
;
Bing WU
;
- Publication Type:Journal Article
- Keywords:
Gastric carcinoma Integrin ? 5? 1 Microvessel density Immunohistochemical staining
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). Integrin ? 5? 1 was significantly over expressed in lymph node metastatic cancer compared with that in corresponding PGC ( t =2.45, P 0.05) and it showed no correlation with integrin ? 5? 1 expression( r = 0.156, P =0.37).Conclusion Over expression of integrin ? 5? 1 is present in GC and associates with the progression of tumor, implying that it may be viewed as the indicator of invasion and metastasis and the candidate target of gene therapy of gastric cancer. However, integrin ? 5? 1 may not play an important role in the vascularization of GC.
