Clinical use of cross reactive groups matching in highly sensitized recipients of kidney recipients
- VernacularTitle:交叉反应组配型在高致敏患者肾移植中的应用
- Author:
Qinghua WANG
;
Jianming TAN
;
Ying WANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Immunization;
Kidney transplantation;
Histocompatibility testing;
Antibody specificity
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of cross reactive groups (CREG) matching in highly sensitized recipients of kidney recipients by testing their serum PRA levels and specificity.Methods The dynamic PRA levels and the specificity were determined. CREG matching was used to select the best donors. Results The preoperative PRA levels in 60 kidney recipients heightened simply or mixedly. Acccording to CREG matching with 0 to 1 MM, 2 MM and 3 to 4 MM, the average recovery time of postoperative creatinine was 6.5 , 7.0 and 12.7 days respectively and the number of the patients with delayed graft function was 0, 7 and 3 respectively.Conclusion There was a great applied value to raise survival rate of patients or allografts for highly sensitized recipients of kidney recipients by CREG matching, to select donors with compatible HLA phenotype or more compatible, to shun the specific antigen of pre existing HLA antibody in recipients and to strictly prohibit HLA repeat mismatches for those retransplantation recipients.
