Implication of expression of lymphotactin mRNA in allografts
- VernacularTitle:急性排斥反应过程中淋巴细胞趋化因子基因表达的意义
- Author:
Xiao GU
;
Xiaoda TANG
;
Shenyang GU
;
Al ET
- Publication Type:Journal Article
- Keywords:
Graft rejection;
Chemokines;
Gene expression;
Heart transplantation;
Rats
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the implication of lymphotactin (LTN) mRNA expression in cardiac allografts and the effect of cyclosporin A (CsA).Methods Three groups of rats underwent the heterotopic cardiac transplantation: isograft group (group A), untreated group (group B) and CsA treated group (group C). The LTN mRNA expression was detected by one step RT PCR method. Results The expression of LTN mRNA was not detected in both isografts and normal hearts. The changes of LTN mRNA expression were correlated with the process of acute allograft rejection. The peak of elevated level of the LTN mRNA expression appeared in the 5th day after transplantation and CsA could delay the peak and downregulate its expression. The peak level of LTN mRNA expression in group C was significantly lower than that in group B ( P
