Evaluation of the infection after allograft and detection of the specific antibodies of toxoplasma gondii in rats
- VernacularTitle:大鼠器官移植术后的弓形虫感染及特异性抗体的检测
- Author:
Hui HAN
;
Hongxing ZHONG
;
Xiaoyan GAO
;
Al ET
- Publication Type:Journal Article
- Keywords:
Toxoplasmosis;
Organ transplantation;
Antibody specificity;
Antigens;
Immunoassay
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the use of CsA and onset of toxoplasma gondii after organ transplantation and study the effect of pathogen acquired path on toxoplasma infectious incidence.Methods ELISA was used to detect recipient's specific CAg and antibodies (IgG, IgM) after organ transplantation of rats. Results The incidence of donor acquired T.gondii infection was higher than that of reactivation of recipient latent infection before operation. The use of CsA could increase the risk of infection by T. gondii after organ transplantation. The use of CsA influenced the detection of anti IgG,IgM sometimes but had no effect in early diagnosis of T.gondii infection through detection of CAg.Conclusion The use of CsA was the main reason leading to infection of toxoplasma gondii after organ transplantion. Detection of specific anti IgG,IgM combined with clinical symptom could be used in early diagnosis.
