Preventive effect of AT1 receptor antagonist on the brain of spentaneously hypertensive stroske-prone rat
- VernacularTitle:血管紧张素1型受体拮抗剂对卒中易感型自发性高血压大鼠脑的保护作用
- Author:
Ke ZHOU
;
Shaozu YU
;
Gengshan LI
;
- Publication Type:Journal Article
- Keywords:
Receptor, angiotensin;
Cerebrovascular accident;
Rats, inbred SHR;
Apoptosis;
Hypertensive rat
- From:
Chinese Journal of Geriatrics
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effects of AT1 receptor antagonist Lorsartan on blood pressure and stroke in spentaneously hypertensive stroske prone rat (SHRsp). Methods Twenty six 6 week aged SHRsp were divided into Losartan 30 mg/kg/d group (n=8), Losartan 10 mg/kg/d group (n=9) and normal saline group (n=9), and 8 sex and age matched Wistar Kyoto(WKY ) as control group (n=8). SHRsp were subjected to 1 5% saline solution as intake and administered 30 mg/kg/d Losartan or 10 mg/kg/d Losartan or equal volume of 0 9% saline solution for 18 weeks by gavage, respectively. The systolic blood pressure was measured by tail cuff sphygmomanometry and clinical score of stroke and survival time of SHRsp were recorded. The coronal brain sections was examined by microscope and electron microscope after decapitation. Apoptosis was analyzed by TdT mediated dUTP biotin nick end labeling and image analysis system. Results Losartan 10mg/kg/d showed no affect on systolic blood pressure but it prevented the occurrence of stroke. The clinical scores of stroke in Losartan 30 mg/kg/d group (0 4?0 7) and Losartan 10 mg/kg/d group (0 7?1 1) were both more decreased than in normal saline group(3 5?0 6) ( P
