Expressions of VEGF, b-FGF,NOS_2 and NOS_3 in human non-small cell lung cancer and the relationship between them and tumor angiogenesis and lymph node metastasis
- VernacularTitle:VEGF、b-FGF、NOS_2和NOS_3在非小细胞肺癌的表达及其临床意义
- Author:
Guiyuan LI
;
Longbang CHEN
;
Jinghua WANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
VEGF;
b FGF;
NOS 2;
NOS 3;
immunohistochemistry;
non small cell lung cancer;
angiogenesis;
lymph node metastasis
- From:China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the expression and distribution of VEGF, b FGF, NOS 2 and NOS 3 in human non small cell lung cancer (NSCLC),and to evaluate the relationship between their expression and tumor angiogenesis and lymph node metastasis.Methods:The expression of VEGF, b FGF, NOS 2, NOS 3 and IMVD in 95 patients with NSCLC were examined using immunohistochemical methods (SP), and the relationship between them and many clinicopathological parameters was analyzed.Results:The positive expression of VEGF and b FGF was associated with intratumor microvessel density(IMVD), TNM stage and lymph node metastases of NSCLC, respectively( P
