Clinical value of examination of p16 protein in lung lesions through fibrobronchoscopic brushing and biopsy
- VernacularTitle:肺部占位性病变纤支镜取材P16蛋白测定的意义
- Author:
Xiaochuan YIN
;
Zhengqing XIAO
;
Gengyun LIU
;
Al ET
- Publication Type:Journal Article
- Keywords:
fibrobronchoscopy;
immunohistochemistry;
lung neoplasmas;
lung benign disease;
p16 protein
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the clinical value of preoperative examination of P16 protein , immunohistochemical method was used to examinate the expression of the protein in tissues obtained through the fibrobronchoscopic brushing and biopsy.Methods:All of the patients who found lesions of lung by radiology were gotten the fibrobronchoscopy to get the spicements. All of the specimens were examinted for expression of P16 protein. The expressions of P16 protein in lung carcinoma group , benign lung disease group and blind biopsy group were compared.Results:The positive expression rates of p16 protein of lung carcinoma group , lung benign disease group and blind biopsy groups are : 55.0%, 95.0% and 62.5%. Conclusions:Difference was found between malignant and benign lung diseases.Examination of p16 protein expression for blind biopsy groups has some values in diagnosis of lung carcinoma.
