Abnromal expression of p53,IGF-IR and PCNA in benign and malignant breast lesions of Han,Uygur woman in Xinjiang
- VernacularTitle:新疆汉、维族妇女乳腺良恶性病变中p53、IGF-IR及PCNA的异常改变及其病理学意义
- Author:
Xiaoli ZHU
;
Zhengzhu SUN
;
Chaolun CHEN
;
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
p53;
IGF IR;
PCNA;
ethnic difference;
immunohistochemistry
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:Detection of p53,IGF IR and PCNA abnormal expression in tumor tissues of Han, Uygur patients with breast benign and malignant lesions may offer more important molecular biologic data of human breast carcinogenesis. Methods:p53?IGF IR and PCNA in 56 breast cancer,38 adenosis, 25 papilloma tissues were dectected by immunohistochemistry (LSAB). Results:The postive frequency of p53 protein, PCNA in breast cancer (58 9%, 98.2%) was found to be notably higher than in benign lesions (4%～5.3%,76%～78.9%) respectively ( P
