Gemcitabine and cisplatin combination in 32 elderly patients with non-small-cell lung cancer
- VernacularTitle:吉西他滨联合顺铂治疗32例老年非小细胞肺癌
- Author:
Qingdong HUANG
;
Jian WU
;
Chunfeng DOU
;
Al ET
- Publication Type:Journal Article
- Keywords:
gemcitabine;
cisplatin;
elderly patients;
non small cell lung cancer
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To evaluate the effect and toxicity of gemcitabine cisplatin combination in elderly patients with advanced NSCLC.Methods:32 elderly patients were treaded with Gemcitabine 1 000 mg/m 2 on day 1,8 and DDP 70 mg/m 2 on day 1. The second treatment cycle was given on day 22.Results:Each patient was given at least 2 cycle chemotherapy. All together 134 cycles were given. The overall response rate (the completed response plus partial response) was 43.8%. The main toxicity was bone marrow depression. The proportion of WHO grade 3 4 hemoglobin, leukocyte and thrombocyte decrease cycles was 7.5%, 12.7%, 23.1%, respectively.Conclusions:Gemcitabine cisplatin combination is effective and well tolerated for elderly patients with NSCLC.
