Strategies of tumor-targeted gene therapy
- VernacularTitle:肿瘤基因治疗的靶向性策略
- Author:
Lintao JIA
;
Chengji WANG
;
Angang YANG
;
- Publication Type:Journal Article
- Keywords:
gene therapy;
tumor;
targeted
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Targeting of tumor cells is crucial for gene therapy of malignant diseases.This can be achieved by tumor targeted gene transfer or tumor specific gene expression, as well as secretion of tumor targeted therapeutic molecules by autologous normal cells.Tumor targeted gene transfer is mediated by the recognition of a class of tumor specific antigens or receptors by corresponding vector fused antibodies or ligands, while therapeutic genes can be selectively expressed in tumor cells under the control of tumor or tissue specific promoters or enhancers, as well as the induction of certain physical, chemical or physiological factors.
