Advances in research on Survivin ,the inhibitor of apoptosis in cancer diagnosis and therapy
- VernacularTitle:凋亡抑制因子Survivin与肿瘤诊治的研究进展
- Author:
Xin YI
;
Xiying QU
;
Musheng LIN
;
- Publication Type:Journal Article
- Keywords:
survivin;
apoptosis;
cell division;
angiogenesis;
molecular diagnosis;
gene therapy
- From:
China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
WTBZ]Survivin belongs to the member of IAP family (inhibitor of apoptosis, IAP) proteins and is a bifunctional protein that suppresses apoptosis and regulates cell division. Survivin is a tumor specific antiapoptosis factor that is expressed selectively in all the most common human carcinomas but not in normal adult tissues. Studies indicated that Survivin played a crucial role in the genesis and progression of malignancy and was an important predictive/prognostic parameter in tumors. Survivin also participates in angiogenesis. Recently, Survivin has been used as a novel diagnostic/therapeutic target in cancer.
