Effect of 5?-reductase inhibitor on vascularity in rats with benign prostatic hyperplasia
- VernacularTitle:5?-还原酶抑制剂对前列腺增生新生血管形成影响的观察
- Author:
Liu LIU
;
Dejiang LIANG
;
Chunlei XIA
;
Guanglin HUANG
;
Yuchen ZHAO
;
- Publication Type:Journal Article
- Keywords:
reductase inhibitor;
Prostatic hyperplasia;
Blood vessels
- From:
Chinese Journal of Geriatrics
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of 5? reductase inhibitor on vascularity of benign prostatic hyperplasia (BPH). Methods Sixty male adult rats were randomly divided into 4 groups (15 per group): normal control, BPH control group, the group of 5? reductase inhibitor treatment during hyperplasia and the group of treatment after hyperplasia. Immunohistochemistry combined with computer assisted image analysis system were performed to examine the expression of factor Ⅷ related antigen, PCNA and VEGF in the prostatic tissue for all rats. Results The microvessel density(MVD) and the expressions of PCNA and VEGF were much less in treatment during hyperplasia and treatment after hyperplusia than that in BPH control group( P
