Expression of transcription factor AP-1 and NF-kappaB in anergic T cells
- VernacularTitle:AP-1与NF-?B的活化表达与T细胞的无能
- Author:
Guilian XU
;
Xihua ZHU
;
Jin YANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Anergy;
AP 1;
NF kappaB
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between transcription factor AP 1 and NF kappaB and IL 2 decrease in anergic T cells.Methods:Nuclear proteins of activated T cells and anergic T cells were extracted and then the expression of AP 1 and NF kappaB were determinated by gel electrophorotic mobility shift assay.Results:Compared to activated T cells,anergic T cells expressed defective AP 1 transcription factor;there were three forms NF kappaB complex in both activated T cells and agergic T cells,but NF kappaB transcription activity was higher in anergic T cells than that in activated T cells.Conclusion:It has been demonstrated that these alteration of transcription factors have been likely to be responsible for repression of IL 2 in anergic T cells.
