Alzheimer-like pathologic changes in hippocampus of middle aged and old aged peole without dementia
- VernacularTitle:中老年非痴呆患者海马区阿尔茨海默样病理改变的分析
- Author:
Jinghua ZHANG
;
Luning WANG
;
Xiang HE
;
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Hippocampus
- From:
Chinese Journal of Geriatrics
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship among Alzheimer-like neuropathologic changes and their relationship with age and sex. Methods From January 1,1986 to April 1,2000,all autopsy caus of non-demented individuals ≥40 years of age in the General Hospital of PLA were examined for Alzheimer-like neuropathologic changes in hippocampus.There were 41 female and 97 male. Senile plaques(SP),neurofibrillary tangles(NFT) were identified with modified Palmgren-stain method. Hirano bodies(HB) or granulovacuolar degeneration(GVD) were identified with HE stain methods. Results About 40% patients had Alzheimer-like neuropathological changes in hippocampus. There was a highly significant correlation was found between the incidence and severity of SP?NFT?Hirano or GVD and patients' age in the CA1 field of the hippocampus, but no significant difference between male and female. There was a strong correlation among the prevalence and numerical densities of these four types of Alzheimer-like changes. Conclusions Alzheimer-like neuropathologic changes were mainly distributed in CA1 of hippocampus. In CA1 they had relationship with age, but no relationship with sex and they had correlation each other.
