Platelet function and endothelial cell disturbance in older non-valve cardiac patients with atrial fibrillation
- VernacularTitle:老年非瓣膜心脏病心房颤动患者血小板功能及血管性血友病因子的改变
- Author:
Jiefu YANG
;
Hua WANG
;
Xiaodong XU
;
Baoli XING
;
Jiabin TONG
;
Xuezhai ZENG
- Publication Type:Journal Article
- Keywords:
Non cardiac valve disease;
Atrial fibrillation;
Blood platelets;
Endothelium
- From:
Chinese Journal of Geriatrics
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate platelet function with special regard to the role of platelet membrane glycoproteins (GPIIb/IIIa?GPIb) and endothelial cell disturbance in the older non valve cardiac patients with atrial fibrillation and their clinical implications. Methods 22 older patients with non valve cardiac atrial fibrillation were studied. There were two age and sex matched control groups, one with 18 patients in sinus rhythm with cardiovascular disease, called the normal sinus rhythm group; the other with 16 health subjects named the health control group. The expression of activated GPIIb/IIIa and GPIb on platelet was analyzed with flow cytometry. Mean platelet volume (MPV) was measured by automatic hematologic analyzer, the plasma vWF was assayed using ELISA. Results The non valve atrial fibrillation group had markedly activated platelet, indicated by increased expression of activated GPIIb/IIIa ( P
