Clinical experience of 2086 cases of kidney preservation
- VernacularTitle:临床肾脏保存2086例经验
- Author:
Changmin HE
;
Hao ZHANG
;
Jun QI
;
Al ET
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Organ preservation;
Preservation solution
- From:
Chinese Journal of Urology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the experience of 20 years in using hypertonic citrate adenine (HC A) for clinical kidney preservation. Methods A total of 2 086 cases of kidneys for transplantation from August 1980 to December 2000 were reported.The donors' age ranged from 18 to 49 years.The cadaveric kidneys were harvested with en bloc method,and were perfused via renal arteries with 250 ml HC A at 2～4 ℃ and 100 cm H 2O, and then stored in HC A at 2～4 ℃ throughout preservation.Serum creatinine was measured at 1 week and 1 month after transplantation.Graft survival rates at 1 year and 3,5,10 years and mean graft survival periods were followed up.According to the cold ischemic time,the cases were divided into 3 groups:Group 1, n =573,with cold ischemic time less than 12 h;Group 2, n =779,with 12 to 24 h;and Group 3, n =734,with more than 24 h. Results The mean cold ischemic period of 2 086 cases was (23.68?4.51)h.The mean level of serum creatinine at 1 week and 1 month after transplantation of all cases was (174.5?125.3)?mol/L and (152.5?107.6)?mol/L,without significant differences among the 3 groups.Abnormal renal function at 1 month after transplantation in 66 cases ( 3.16 %) was associated with kidney preservation.There were no differences in graft survival rates at 1 year and 3,5,10 years after transplantation,with graft survival rate at 5 and 10 years in Group 2 reaching 63% and 52%,respectively.The mean graft survival period in Group 3 was significantly less than that in Group 1 and Group 2 ( P
