Correlation between tumor necrosis factor ? gene promoter polymorphisms and acute rejection following renal transplantation
- VernacularTitle:肿瘤坏死因子?基因启动子多态性与肾移植术后急性排斥反应的关系
- Author:
Lei YANG
;
Hong CUI
;
Yongfeng LIU
;
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Tumor necrosis factor;
Gene polymorphisms;
Acute rejection
- From:
Chinese Journal of Urology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of cytokine tumor necrosis factor ? (TNF ?) gene promoter 308 position polymorphisms in predicting acute graft rejection following renal transplantation. Methods In 35 preoperative recipients,TNF ? produced by peripheral blood cells was measured by enzyme linked immmunosorbent assay,and their TNF ? gene promoter 308 position polymorphisms were determined by PCR restriction fragment length polymorphisms(PCR RFLP).The association between TNF ? gene promoter polymorphisms and production of them was studied.Furthermore,the correlation between their polymorphisms and acute rejection in the first 3 months after renal transplantation was discussed. Results The recipients with A/A or A/G genotype in TNF ? promoter 308 position secreted more cytokine (624.96?177.78)pg/ml and (544.32?132.42)pg/ml than those with G/G (233.16?25.37)pg/ml, P
