Expression of COX-2,p53 and PCNA in esophageal carcinoma and its significance
- VernacularTitle:食管癌组织中COX-2、p53和PCNA的表达及意义
- Author:
Sujuan FEI
;
Shuiping HUANG
;
Lixin ZHOU
;
Al ET
- Publication Type:Journal Article
- Keywords:
esophageal carcinoma;
cyclooxygenase 2;
P53 protein;
proliferative cell nuclear antigen
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of COX 2,P53 and PCNA in esophageal carcinomas and its significance. Methods:Immunohistochemical method was used to examine the sections from 82 esophageal squamous cell carcinomas, 20 esophagitis and 16 normal esophageal mucosa tissues. Results:The positive ratios of COX 2,p53 and PCNA were 87.8%(72/82),82.9%(68/82)and 95.1%(78/82) in 82 esophageal carcinomas, respectively. But there was no expression in adjacent noncancerous tissues and normal esophageal mucosa tissues. The positive ratio of COX 2 protein was significantly higher in the well differentiated and moderately differentiated esophageal carcinomas than in the poorly differentiated esophageal carcinomas( P
