Prediction of lymph node metastasis and the expression of cancer associated genes in endoscopic biopsy specimens of stomach cancer
- VernacularTitle:胃癌活检标本癌转移相关基因表达与淋巴结转移的预测
- Author:
Wei ZHOU
;
Xia HUANG
;
Jingshun RU
;
Al ET
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
lymphnode metastasis;
gene expression;
immunohistochemistry
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the correlation between lymph node metastasis(LNM) and the expression of 10 cancer associated genes in endoscopic biopsy specimens of stomach cancer and to investigate their value in predicting metastasis.Methods:The expression of CD44V6,E cadherin, VEGF, EGFR, P53, nm23 H1, Fas, FasL, Cath B, Cath D was detected by immunohistochemistry in 44 endoscopic biopsy specimens and correlated to the incidence of LNM. Results:The LNM of stomach cancer was positively correlated with the level of expression of VEGF and EGFR, but negatively correlated with that of Fas expression. Co expressions of VEGF(+)EGFR(+), VEGF(+)E cadherin( ), VEGF(+)Fas( ) and EGFR(+)Fas( ) were related with the LNM respectively. The sensitivity and specificity for predicting LNM were low when 3 single index was observed. The specificity for predicting LNM was increased, but the sensitivity was very much decreased when 4 co indexes were observed. Conclusions:The examination of cancer associated genes in endoscopic biopsy specimens of stomach cancer is of no clinical significance in predicting LNM of stomach cancer.
