Significance of NF-?B expression in human cerebral tumors
- VernacularTitle:核因子-?B在人脑肿瘤中的表达及意义
- Author:
Baodong CHEN
;
Xianhou YUAN
;
Pucha JIANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
nuclear factor of kappa B;
astrocytic tumor;
medulloblastoma;
meningioma;
immunohistochemistry
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To evaluate the significance of NF ?B P65 protein expression in various human cerebral tumors. Methods:The expression of NF ?B P65 protein in 106 cases of cerebral tumors was studied immunohistochemically. 106 cases included 64 cases of astrocytic tumors and 22 cases of medulloblastoma and 20 cases of meningioma. 10 cases of normal brain tissue were employed as a control group.Results:The positive rate of NF ?B P65 protein of 64 astrocytic tumor specimens was 54.7%; the positive rate of NF ?B P65 protein of 22 cases of medulloblastoma was 36.4% and 5.0% for 20 cases of meningioma. In contrast, none of the normal tissues exhibited NF ?B P65 protein staining. Significant difference were observed between astrocytic tumor group and meningioma, as well as between medulloblastoma and meningioma ( P
