HLA-DRB1 alleles and susceptibility to multiple sclerosis
- VernacularTitle:HLA-DRB1基因型与多发性硬化易患性
- Author:
Kang WANG
;
Guoxiang WANG
;
Xingzhou LIU
;
Al ET
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
HLA DR antigens;
Twins;
Pedigree;
Genotype;
Gene frequency
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the polymorphism of the HLA DRB1 gene in patients with MS,as to explaining the differences of clincal features and pathology between Caucasian and Asian Methods Thirty patients with MS including 2 twin families and 40 normal controls were studied by genotype of HLA DRB1 using PCR SSP Results Monozygotic twins identified by microsatellite markers were affected in spinal cord,brain and pons The genotype of them was HLA DRB1*09*14 1 One of the dizygotic pair whose genotype was HLA DRB1*01*12 was a patient with neuromyelitis optica while her normal sister was HLA DRB1*17*12 The ratio of case number of Western type MS and Asian type was 1∶1,and no difference existed in age at onset,duration and gender between two types It’s different from Caucasian that the most involved locations were spinal cord (this study 70 0%) and optical nerve (56 7%) The frequency of HLA DR15 in MS was higher than in controls (13/30 vs 10/40),but not significant (? 2=2 611 8, P =0 106 1),however,the DR12 allele was strongly associated with optico spinal type (8/15 vs 4/40, RR =5 33,? 2=9 603 0, P =0 001 9),but not associated with Western MS Conclusion The difference of concordance between monozygotic and dizygotic twins suggested that the susceptibility of MS was affected by genetic factors Association between HLA DR12 and optico spinal type MS in northern Chinese was suggested,which may be one of the genetic causes of the differences in manifestation and pathology
