Pathological and clinical analysis of peripheral nerve’s injury in patient with multiple sclerosis
- VernacularTitle:多发性硬化周围神经损伤的病理与临床分析
- Author:
Runjin LI
;
Zhimin QIAN
;
Lijun GUO
;
Al ET
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis system diseases;
Peripheral nervous;
Demyelinating;
Sural nerve
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the pathological features in 12 patients demonstrated with demyelination lesions of peripheral nerves Methods Twelve abnormaly cases were screened with EMG from 60 cases of multiple sclerosis (MS) Sural nerve biopsy was done in 12 patients and specimens were analyzed by HE and Loyez,and by electronic microscopy Results Myelinated fibers was reduced in sural nerve biopsy in 8 cases and most striking demyelination seen in 11 cases In electronic microscopy,11 cases specimens were shown myelinated losses,regeneration of myelinated fibers,vacuoate,hyperplasia of Schwann cell and typical onion bulb formation 8 cases of the large thickened fibers showed increased members of myelin lamellae Conclusion MS is charaterized by inflammatory demyelinating disorder limited to the CNS And some patients' peripheral neves are also shown sectionally demyelinated injury.
