Effect of vascular endothelial growth factor on myocyte apoptosis of rats with acute myocardial infarction
- VernacularTitle:血管内皮生长因子对急性心肌梗死大鼠心肌细胞凋亡的影响
- Author:
Ruixing YIN
;
Jiaquan LI
;
Jie CAI
;
Dezhai YANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Endothelial growth factors;
Apoptosis
- From:
Chinese Journal of Geriatrics
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effect of intravenous administration of vascular endothelial growth factor (VEGF) on myocyte apoptosis and the expression of P 53 , Fas, Bax and Bcl 2 in an experimental model rat with acute myocardial infarction Methods Thirty three male Sprague Dawley rats were subjected to left coronary artery ligation The rats were randomized to receive VEGF 165 heparin(treated group) or heparin saline(control group), respectively, 24 hours after surgery VEGF 165 (2 ?g/1 ml)with heparin(50 U)or heparin saline(50 U/1 ml)was administered daily via tail vein for 7 days(treated group, n=8;control group, n =10) and 14 days(treated group, n=7;control group,n =8)separately Apoptotic index and the expression of the P 53 , Fas, Bax and Bcl 2 in myocardium were measured at 9 or 16 days after coronary artery ligation Results The number of apoptotic myocytes in VEGF treated group was less than that in control group\[(10?2)% vs (28?2)%, P
