Apoptosis and p53 gene expression of fibroblasts in hypertropicscars and keloids
- VernacularTitle:瘢痕成纤维细胞凋亡及p53基因的表达
- Author:
Yong HUANG
;
Jing CHEN
;
Lixin LIN
;
Al ET
- Publication Type:Journal Article
- Keywords:
Cicatrix;
Keloid;
Fibroblastapoptosis;
Genes ,p53
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2002;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Tostudythecellapoptosisandp5 3geneexpressionoffibroblastsisolatedfromdifferenttissues .Methods Thefibroblastsfrom 8casesofnormalskin ,8hypertrophicscarsand 9keloids wereculturedrespectivelyinvitro.Flowcytometryanddotblotanalysisofp5 3withcDNAprobewereappliedandtheirbiologicalpropertieswerecomparedinthisstudy .Results Apoptoticcellsofthreegroupswereasfollows:(10 .8? 1.2 ) % ,(10 .6? 1.8) %and (5 .5? 0 .8) % ,respectively .Theresultsrevealedthatthere werefewerapoptoticcellsinkeloidthanthoseinhypertrophicscarandnormalskin (P
