Relationship between cytokine gene polymorphisms and acute rejection after renal transplantation
- VernacularTitle:细胞因子基因多态性与肾移植急性排斥反应的关系
- Author:
Lizhong CHEN
;
Xintao ZHANG
;
Jiong BI
;
Al ET
- Publication Type:Journal Article
- Keywords:
Gene expression;
Immunologic and biological factors;
Kidney transplantation;
Graft rejection
- From:
Chinese Journal of Organ Transplantation
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cytokine genotypes of the renal transplantation recipients with or without acute rejections.Methods The cytokine genotypes of peripheral blood TNF ?, TGF ? IL 6 and IFN ? in 89 kidney to allograft receipients were detected by using PCR method. According to the test, the occurrence of acute rejection was compared among the groups. Results TNF ? and IFN ? high producer genotype (-308 GA and AA) showed a correlation with the high incidence of acute rejection to the HLA DR mismatching recipients. Conclusion To detect the cytokines gene polymorphisms before operations can find the high risk kidney receipients who may suffer from the acute rejection. It's very helpful in guiding the individual use of immunosuppressants following the renal transplantation.
