Neoral C_2 predicting drug hepatic toxicity following renal transplantation in hepatitis patients
- VernacularTitle:血清肝炎病毒标志物阳性或肝炎患者肾移植后测定环孢素C_2的意义
- Author:
Shi QIU
;
Long LIU
;
Liming ZHAO
;
Al ET
- Publication Type:Journal Article
- Keywords:
Cyclosporins;
Drug toxicity;
Drug monitoring
- From:
Chinese Journal of Organ Transplantation
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical implication of Neoral C 2 in evaluating drug hepatic toxicity following renal transplantation in hepatitis patients. Methods 162 cases receving renal transplantation were divided into two groups: positive group with positive hepatitis B and(or) C viral antigens or de finite hepatitis history before renal transplantation ( n =51) and the remaining 111 cases served as normal control group. One week posttransplantation, the blood concentrations of cyclosporins at 0 (C 0) and 2 (C 2) h after administration were determined. Results In the positive group, C 2, not C 0 one week postoperation was higher than normal control group ( P
