Expression of NOS in bladder transitional cell carcinoma
- VernacularTitle:一氧化氮合成酶在膀胱癌中的表达及意义
- Author:
Kunjie WANG
;
Hong LI
;
Yuru YANG
;
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Nitric oxide synthase;
Carcinoma,transitional cell
- From:
Chinese Journal of Urology
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of different kinds of nitric oxide synthase(NOS)in the growth and angiogenesis of bladder transitional cell carcinoma. Methods Bladder transitional cell carcinoma tissue specimens were procured from 25 patients undergoing cystectomy, and compared with 6 normal bladder tissue specimens from donors in renal transplantation. Immunohistochemical staining was performed to detect the expression of 3 kinds of NOS. Results The malignant epithelial cells showed strong positive on immunohistochemistry whereas normal bladder showed only a weak positive iNOS immunostaining. The endothelial cells of precapillary vessels in the stroma of carcinoma showed a highly positive endothelial NOS (eNOS) immunostaining as compared with the stroma of normal bladder tissue. The expression of neuronal NOS(nNOS) was found in fibers in the fibromuscular stroma of the two groups. Conclusions Bladder transitional carcinoma tissue had a higher content of iNOS and which might be related to the genesis and development of bladder carcinoma.
