The effect of interlenkin 6 on the growth of LNCaP and PC-3 prostatic carcinoma cells
- VernacularTitle:白介素-6对前列腺癌细胞生长的作用
- Author:
Xiaodong ZHANG
;
Bo ZHANG
;
Yongpeng GU
;
Al ET
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Carcinoma;
Interlenkin 6;
Cells,cultured
- From:
Chinese Journal of Urology
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of IL 6 on prostatic carcinoma cell lines,and differential effects on androgen dependent and androgen independent prostatic carcinoma cells. Methods The IL 6 producing capacities of LNCaP and PC 3 cells were determined,and effects of exogenous IL 6 and anti IL 6 antibodies on LNCaP and PC 3 cells were examined. Results LNCaP produced a very small amount of IL 6,but PC 3 produced more,the concentration of IL 6 being 190 pg/48h per ml(1?10 6).The exogenous IL 6 inhibited LNCaP growth significantly,but had no obvious effect on PC 3 cells.Anti IL 6 antibidies lowered PC 3 cells growth rate but had neutral effect on LNCaP. Conclusions PC 3 cells produces IL 6 massively in autocrine manner.IL 6 could be antagonized by anti IL 6 antibodies,resulting in slowing PC 3 cells growth,and LNCaP cells growth could be inhibited by exogenous IL 6.
