Radiation-induced fibrosis in rat lung: Modification by hydroxypiperquin phosphate
- VernacularTitle:磷酸羟基哌喹对大鼠放射性肺纤维化的防治作用
- Author:
Mei WANG
;
Qiang FU
;
Bi-He MING
;
Al ET
- Publication Type:Journal Article
- Keywords:
hydroxypiperquin phosphate;
radiation-induced pulmonary fibrosis;
rats;
hydroxyproline;
pathological changes
- From:China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To evaluate the HPQP as a modifier of radiation-induced pulmonary fibrosis in rats sacrificed 4 months and 6 months separately after a single dose of 0, 15, 20, 25 Gy60Co r rays to the right hemithorax. Methods: HPQP was administered by a stomach tube 2 times a week after irradiation at a regimen of 100mg/kg. Pulmonary fibrosis was evaluated by lung hydroxyproline( HP) content and histological observation( LM and EM). Results: The content of lung HP increased with increasing radiation dose. The differences between control group and 20,25 Gy group are significant P
