Preliminary study on antitumor effect of active specific immunotherapy with autologous tumor vaccine in post-operative patients with advanced tumors
- VernacularTitle:自体肿瘤疫苗主动特异性免疫治疗进展期肿瘤的初步研究
- Author:
Demao YAO
;
Yili WANG
;
Mao MA
;
Al ET
- Publication Type:Journal Article
- Keywords:
Advanced tumor Active specific immunotherapy Autologous tumor vaccine Specific response Cellular immune
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The explore the mechanism of active immunotherapy with autologous tumor vaccine and clinical significance.Methods:30 patients with advanced tumors were enrolled in this study.4 weeks after operation,the patients received vaccinations of autologous tumor vaccine every 7～10 days for 4 times as adjuvant active immunotherapy,3 days before and 7 days after administrations:peripheral blood monuclear cells(PBMC) were isolated to assay the alteration of proportions of CD + 8 IFN ? + and CD + 8 IL 10 +,CD + 4 IFN ? + and CD + 4 IL 10 + cells.Meanwhile,serum IFN ? and IL 10 were measured within 48 hours after the skin tests with PPD and autologous tumor antigen,diameters of erythemas or indurations were observed.The clinical follow up was performed.Results:After active immunotherapy with autologous tumor vaccine.①The serum IFN ? was increased from (5.98?2 40)pg/ml to (11.20?4.76) pg/ml(P
