Expression of CD28-B7 costimulatory molecules on peripheral blood cells in myasthenia gravis
- VernacularTitle:重症肌无力外周血单个核细胞CD28-B7共刺激通路相关分子的表达
- Author:
Zhao HAN
;
Rongyuan ZHENG
;
Hongyu LIU
;
Al ET
- Publication Type:Journal Article
- Keywords:
Costimulatory molecules Myasthenia gravis CD28
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the pathogeny and expression of CD28 B7 costimulatory molecules on peripheral blood cells in myasthenia gravis.Methods:Expression of CD28?CTLA4 and their ligants B7 1?B7 2 on CD4 + and CD8 + T lymphocytes in 18 patients with MG and 16 healthy controls were examined by flow cytometry.Results:In MG group,the expression of CD28?CTLA4?B7 1?B7 2 molecules were increased.The increased CD28 + cells were mainly of CD4 +T lymphocytes subset.The increased CTLA4 + cells were mainly of CD8 + T lymphocyte subset;There was no significant difference in the expressions of B7.1 and B7.2 molecules on CD4 + or CD8 + T lymphocytes between two groups.Conclusion:The pathogeny of myasthenia gravia is associated with the increased expression of CD28 B7 costimulatory molecules.Examining of CD28 B7 costimulatory molecules on peripheral blood cells may reflect the immune state of MG patients,and is helpful to the diagnosis and treatment.
