Expression of MIP-1? and significance in patients with lupus nephritis
- VernacularTitle:MIP-1?在狼疮肾炎患者肾组织的表达及意义
- Author:
Daoyuan ZHOU
;
Youji LI
;
Ming LIANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Lupus nephritis In situ hybridization Macrophage inflammatory protein 1?
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect MIP 1? mRNA in kidney specimens in lupus nephritis(LN) patients and investigate its association with clinical and pathological features.Methods:MIP 1? mRNA were identified by in situ hybridization.Results:MIP 1? mRNA were detected in gromeluli,cortical tubular cells and interstitum of LN specimens wherase no MIP 1? mRNA was found in normal specimens.There were especially obvious MIP 1? expression in IV type LN specimens.MIP 1? expression in LN gromeruli,tubular cells and interstitium were correlated positively with LN histological activity index.Conclusion:There were enhancement of MIP 1? mRNA expression in LN kidney specimens,especially in IV type LN.MIP 1? expression in LN specimens were related with active inflammatory injury of glomeruli and tubulointerstitium.
