Expression of CD44v6 protein in human breast carcinoma and its relevance for prognosis
- VernacularTitle:CD44v6蛋白在乳腺癌中的表达及其预后意义
- Author:
Lin-Xiang SHI
;
Hai-Bao TONG
;
Qing LI
;
Al ET
- Publication Type:Journal Article
- Keywords:
breast carcinoma;
CD44v6;
metastasis;
prognosis
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of CD44v6 protein in breast carcinoma and its prognostic significance. Methods:100 cases of formalin-fixed paraffin-embeded female breast invasive ductal carcinoma tissues were retrospectively analyzed using EnVision~(TM) immunohistochemical method with the monoclonal antibody CD44v6.Statistical analysis was based on the Log-rank test and Cox analysis.Results:Sixty-six of 100 cancer tissues expressed CD44v6.Positive staining was mainly on the cell membranes.There was significant correlation between CD44v6 immunoreactivity and lymph node me- tastasis and TNM stage.The 5-and 10-year survival rates were 82.76% and 78.37% of patients with CD44v6 low-expres- sion tumors,and 64.1% and 49.88% of those with CD44v6 high-expression tumors,respectively;the difference between the two groups of patients was significant(P
