Influence of high dose progesterone on telomerase activity in patients with carcinoma of endome-trium
- VernacularTitle:大剂量孕激素治疗对子宫内膜腺癌端粒酶活性的影响
- Author:
Jing-Xin CHENG
;
Ting-Fang LI
;
Qing LIU
;
Al ET
- Publication Type:Journal Article
- Keywords:
endometrial neoplasm;
progesterone;
telomerase
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the influence of treatment with high dose progesterone on telomerase activity in patients with endometrial adenocarcinoma.Methods:20 patients were treated for adenocarcinoma of endometrium with high dose progesterone and the change of telomerase activity in tumor tissue was examined by PCR-TRAP ELISA before and after treatment.Results:The average A value of tumor telomerase before and after treatment were 0.3636(0～1.11) and 0.1134 (0～0.556),respectively.It shows that telomerase activity in tumor was decreased by treatment with progesterone (P
