Distribution of human papillomavirus and its subtypes in tissue samples of Uigur cervical cancer from southern Xinjiang
- VernacularTitle:人类乳头瘤病毒及其亚型在新疆南部地区维族妇女宫颈癌组织中的分布
- Author:
Kurban GULINAR
;
Mamat AYNUR
;
Abliz GUZALNUR
;
- Publication Type:Journal Article
- Keywords:
cervical neoplasm;
human papillomavirus;
polymerase chain reaction;
southern Uigur
- From:China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the association between human papillomavirus (HPV) and cervical cancer in Uigur women from southern Xinjiang where there is a high risk of cervical cancer.Methods:HPV-C,HPV16,HPV18 and HPV6/ 11 were detected in 40 fresh tissues of cervical cancer and 40 tissues of normal cervix by using polymerase chain reaction technique.Results:The positive rate of HPV-C,HPV16,HPV18 and HPV6/11 in fresh tissue of cervix cancer were 87. 5%,72.5%,10.0% and 0,respectively;The positive rate of HPV-C,HPV16,HPV18 and HPV6/11 in normal cervix were20.0%,5.0%,0 and 7.5%,HPV16 was the most common type in HPV-C positive patients with the rate of 82.8 %. The positive rate of HPV-C and HPV16 in cervical cancer were significantly higher than that in control groups;The positive rate of HPV16 in squamous cancer of cervix was significantly higher than that in adenocarcinomas of cervix;while the posi- tive rate of HPV 18 in adenocarcinomas of cervix was significantly higher than that in squamous cancer of cervix(P0.05).Conclusions:HPV16 infection plays an important role in the carcinogenesis of cervical cancer of Uigur women from Southern Xinjiang,HPV16 infection is closely correlated with squamous carcinomas of cervix,while HPV18 infection is closely correlated with adenocarcinomas of cervix.The positive rate of HPV-C and HPV16 have no correlation with clinical stages and histological grade of cervical carcinomas.
