Oxaliplatin combined fluorouracil and calcium folinate in the treatment of 37 cases with advanced colorectal cancer
- VernacularTitle:奥沙利铂与氟尿嘧啶、亚叶酸钙联合治疗晚期大肠癌
- Author:
Xiao-Bo DU
;
Hong WANG
;
Hui LI
;
Al ET
- Publication Type:Journal Article
- Keywords:
advanced colorectal cancer;
oxaliplatin;
fluorouracil;
calcium folinate
- From:China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the response and toxicity of the regimen of oxaliplatin combined with fluorouracil and calcium folinate in the treatment of consisting of advanced colorectal cancer.Methods:Thirty-seven patients with advanced colorectal cancer received chemotherapy of regimen:oxaliplatin 130 mg/m~2 2 hours iv on day 1,calcium folinate 200 mg/ m~2 iv 2 hours on days 1 to 5,followed by fluorouracil 300 mg/m~2(≤500 mg/d) iv 4 h on days 1 to 5,three or four weeks as one cycle.Results:The total response rate was 29.7%,the main toxicity was bone marrow suppression and neuro-sensory toxicity,leukopenia was observed in 45.9% of the patients,but grade Ⅲ and Ⅳ in only 8.1%,neuro-sensory toxicity was observed in 81.9.%,but grade Ⅲ and Ⅳ in only 5.4%.Conclusions:This study shows that the regimen of oxaliplatin combined fluorouracil and calcium folinate is effective and tolerable in advanced colorectal cancer therapy.
