Synergistic effects of toremifene and anti-tumor drugs on human lung cancer cell lines A549
- VernacularTitle:托瑞米芬与化疗药物协同抑制肺癌A549细胞生长
- Author:
Xue-Yan ZHANG
;
Qiang LI
;
Zhong-Ling LIU
;
Al ET
- Publication Type:Journal Article
- Keywords:
lung neoplasm;
toremifene;
anti-tumor drugs;
synergistic effect
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the activity of toremifene and its synergistic effect with anti-tumor drugs on human lung adenocarcinoma cell line A549,which might be expected to provide a new mode of therapy for the clinical management of lung cancer.Methods:The cytotoxic effects of these agents on human lung cancer cell line A549 were measured by a tet- razolium-based volorimetric assay (MTT assay).Results:Toremifene can inhibit the growth of A549 cell directly.The A value of the low dose toremifene combined with anti-tumor drugs were lower than that of anti-tumor drugs alone.Toremifene combined with VCR,ADM,DDP and VP-16 showed better effects.Conclusions:Toremifene combined with chemotherapy drugs shows significant synergistic anti-tumor effect on A549 cell.This might provide experimental evidence for lung cancer therapy.
