Study on the analogue of Somatostatin for colorectal cancer
- VernacularTitle:生长抑素类似物对结肠癌治疗作用的实验研究
- Author:
Zhenyu WANG
;
Chunning ZHENG
;
- Publication Type:Journal Article
- Keywords:
Somatostatin;
Colonic neoplasms;
Mice,nude
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To confirm the analogue of Somatostatin OCT and NC 8 12 on the colon tumor cell growth in vitro and vivo.Methods:(1)Two colon cancer cell lines HCT116,LOVO of which cell proliferation was measured with MTT were treated with different analogue of Somatostatin in vitro.(2)The nude mice were implanted s.c.with colon cancer cell line HCT116,then were injected s.c. with OCT and NC 8 12.Results:(1).Cell proliferation of HCT116 induced by Insulin was obviously inhibited by OCT or NC 8 12 at 10 -8 mol/L 24h later after the cells were incubated with them.(2)The nude mice bearing xenografts of colon cancer HCT116 were treated for 21days subcontinuously with OCT?NC 8 12?g/(kg.d)],the inhibitory effect was seen obviously.,the inhibitory effect was seen obviously.Conclusion:The Somatostatin analogues OCT and NC 8 12 can inhibit the proliferation of colon cancer cells in vitro and vivo directly.
