Study of viral vector for mutagenesis in tumor genetherapy
- VernacularTitle:病毒载体致突变性的实验研究
- Author:
Heshu LI
;
Dianjun LI
;
Dalin LI
;
Al ET
- Publication Type:Journal Article
- Keywords:
Retrovirus Adenovirus Cancer gene therapy Ames Micromuleus
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe mutagenesis of retrovirus and adenovirus as transgenic vector,and provide safe clinic evidence for transgenic tumor cell as tumor vaccin.Methods:Cells were cultured together with virus.Then,DNA and supernatant were carried on an in vestigation in mutagenesis by means of laboratory technique about genetic toxicology.Results:The result indicated that DNA and supernatant of transgenic cell had no mutagenesis through test both In vivo and in vitroConclusion:The virus modified had no mutagenesis as transgenic vector.
