The expression of adhesion molecules on peripheral blood leucocyte in patients with multiple sclerosis
- VernacularTitle:多发性硬化患者外周血白细胞粘附分子的表达
- Author:
Bin XIA
;
Zhongxin ZHAO
;
Lingzhen ZHANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis Flow cytometry Methylprednisolone Intercellular adhesion molecules 1
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the levels of adhesion molecules in peripheral blood leucocyte from patients with multiple sclerosis(MS) and after intravenous methylprednisolone(MP) treatment.Methods:The positive percentag of intercellular adhesion molecule 1(CD54)?integrin LFA 1 ? subunit(CD18)?very late antigen 4 ??? subunit(CD49d?CD29) and L selectin(CD62L) were determined on lymphocytes and monocytes by flow cytometry from 28 patients with relapsing remitting MS (relapses n=20,remission n=8) and 20 controls.Results:The positive percentage of CD49d?CD29 on lymphocytes and monocytes,CD54 and CD62L on monocytes in relapses MS group were higher than in remission MS group and controls(P0.05).Conclusion:The adhesion molecules expression on peripheral blood leucocyte were elevated in MS patients and it may be suitable to be as a marker of MS activity.
