The clinical value of the peripheral blood ICAM-1 level in Graves' disease
- VernacularTitle:Graves病患者外周血细胞间粘附分子-1水平检测的临床价值
- Author:
Fengling MENG
;
Guozhen NAN
;
Shengou SU
;
- Publication Type:Journal Article
- Keywords:
Graves's disease Intercellular adhesion molecule 1 Cellular immunity Humoral immunity
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value on the determination of the peripheral blood ICAM 1 level in Graves's disease(GD).Methods:The serum soluble Intercellular Adhesion Molecule 1(sICAM 1)concentration were analyzed by ELISA and the expression of ICAM 1(CD54 +) on PB lymphocytes in 37 GD patients and 22 normal subject were measured,while TsAb,TpoAb,TGAb;CD4 +,CD3 +,CD8 +,CD19 +,CD25 +were examined by FACS.Each marker between the two groups and the positive rate between the TsAb and sICAM 1 whe compared.In addition ,the relationship between the ICAM 1 level on PB and immunity markers in GD patients were analysed.Results:The mean sICAM 1 concentration was significantly higher in untreatd GD patients than in normal controls(P
