Expression of P16 and P15 in human gastric carcinoma and metastatic lymph node
- VernacularTitle:P16、P15基因在胃癌及转移淋巴结中的表达
- Author:
Peng XIAO
;
Guangbin CHEN
;
Junheng BAI
;
Al ET
- Publication Type:Journal Article
- Keywords:
primary gastric carcinoma;
P16 P15;
immunohistochemistry;
lymph node
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the expression of tumor suppressor genes P16 and P15 in human primary gastric carcinoma(PGC) and metastatic lymph node(MLN) in order to explore their roles in carcinoma metastasis and the prognosis of PGC.Methods:The expresion of P16 and P15 was detected by SP immunohistochemical method in 92 cases of PGC and 138 MLN. All samples were obtained fresh, fixed with 10% buffered formalin immediately, embedded with paraffin and then sectioned serially. Results:The positive expression rates of P16 and P15 were 17.45% and 28.3% in PGC, and 15.95% and 28.3% in MLN respectively. The positive expression rates of P16 and P15 in PGC with lymph node metastasis was lower than that without lymph node metastasis ( P
